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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

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Two Very Different Drug Classes Phentermine hydrochloride is a sympathomimetic amine anorectic, indicated as a short-term adjunct the labeling says "a few weeks" in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction, in the management of exogenous obesity for patients with an initial body mass index of 30 kg/m or greater, or 27 kg/m or greater in the presence of other risk factors such as controlled hypertension, diabetes or hyperlipidemia

By highlighting the therapeutic potential of GLP-1RAs, we demonstrate their value as both a preventative and therapeutic strategy against ischemic stroke

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