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On GLP-1 medications, you're fighting three dehydration mechanisms simultaneously: Reduced thirst signaling (central appetite suppression affects thirst centers) Reduced fluid intake with meals (nausea makes drinking unpleasant) Ongoing fluid loss from glycogen metabolism during weight loss The result is chronic mild dehydration in a substantial portion of patients during titration
We ask all our patients to log into the portal once a week
The following schedule applies across all Child-Pugh classes, with frequency adjusted upward for higher severity
10.1182/blood-2009-09-245977 135 SatoY.MizuguchiT.ShigenagaS.YoshikawaE.ChujoK.MinakuchiJ.et al (2012)
This sequence is thought to be a small fraction of the large protein collagen, which is one of the main proteins in the extracellular matrix of skin and other tissues
Taking tirzepatide early or late occasionally is fine, but consistently irregular dosing leads to fluctuating drug levels, inconsistent appetite suppression, and suboptimal results
