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4 In SUMMIT, in which half of the participants had T2D, tirzepatide reduced weight, improved KCCQ-CSS and 6MWD, and also decreased worsening HF events by 38%, with no heterogeneity by T2D status

Hammerman C, Bin-Nun A, Markovitch E et al , Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment

Whole cell GSH abundance (bottom left) and fold change in cell number (log 2 ) of HEK-293T cells expressing a vector control or engineered GshF cDNA treated with indicated BSO concentrations for 5 days (bottom right)

Likewise, reports of FGF21 increasing water intake and blood pressure in rodents, potentially by stimulating sympathetic pathways (313, 314) do not appear to translate consistently to humans, with one study (293) but no others (183, 244246, 315) suggesting an effect

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B., Pavic, P., Mestrovic, T., Sjekavica, I.,