Different mechanisms, different side-effect profiles
Well, almost anything
Investigating Toxic Overload and Depression A targeted history and laboratory assessment may help distinguish environmental exposure from elevated SAH, glutathione depletion, mitochondrial stress, gut-derived burden or impaired organ clearance
They are chemically distinct: copper binding alters charge, conformation, and the chemistry researchers are usually probing, so the two are not interchangeable in experimental design
you must still wear topical SPF to prevent UV rays from triggering the very pigment you are trying to manage
doi:10.1001/jamadermatol.2015.3029 16Mercer LK, Askling J, Raaschou P,