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(4) Another way in which berberine works is by activating an enzyme within our body cells called AMP-activated protein kinase (AMPK)

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Studies in mice, however, have shown that Nestin expression in brain reaches a nadir around 18 days of life and that most cells that express Nestin postnatally are relatively inactive in adulthood unless an injury, such as hypoxia to the brain, occurs (3335)

Mukherjee AJ, Zade SS, Singh HB, Sunoj RB

A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig