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(Table 1) Results European POAG GWAS identifies newly associated variants near genes with known roles in eye development and function The analysis of individuals of European ancestry (2,302 POAG cases, 213,774 controls) identified 52 genome-wide significant variants and five distinct loci associated with POAG, consistent with previous GWAS findings related to POAG and visual field loss 24

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Seventh, our primary efficacy analyses targeted an on-treatment estimand and, therefore, may overestimate effectiveness compared with a treatment-policy (all-exposed) approach