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The most common compounding-pharmacy guidance is to reconstitute a 5 mg vial with 2 mL of BAC water, giving a 2.5 mg/mL concentration that places the standard Wegovy titration ladder (0.25 / 0.5 / 1 / 1.7 / 2.4 mg weekly) at convenient, easy-to-draw syringe-unit values
503B facilities must register with the FDA, comply with current good manufacturing practices (cGMP), and submit to regular inspections
Reconstitution volume depends on the target concentration per study endpoint
Another path involves discontinuing semaglutide while implementing intensive lifestyle modificationsstructured diet, consistent exercise, and behavioral coaching
Exercise helps maintain metabolic rate, preserves insulin sensitivity, and partially compensates for the loss of tirzepatide's metabolic effects
Category 3: The persistent experimenters (approximately 10%)
