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La FDA requiere demostracin rigurosa de biodisponibilidad, eficacia clnica y seguridad antes de aprobar cualquier nueva va de administracin
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GLP-1 medications are contraindicated or require careful evaluation in these situations: Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) History of pancreatitis Severe gastroparesis or other conditions where slowed gastric emptying is dangerous Pregnancy or planning to become pregnant
There was, however, a dose-dependent decrease in distance traveled
Dec 1997;68(6):981-6
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