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Sleep (2017)
America Has a New GLP-1 Playbook First a shot to lose weight, then a pill to keep it off
A.GullionC
Meanwhile, dual agonists, which target and activate both the GLP-1 (Glucagon-like peptide-1) receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor, and triple agonists (targeting the GLP-1+GIP+Glucagon receptors) are also showing promise
Although the enrichment of L-cells by pharmacological agents can be a novel approach for improving insulin secretion, glucose tolerance and the treatment of T2DM, more research for the specific differentiation of L-cells and the translation of in vitro and animal data to humans, are needed for the success of this approach
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