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However, we monitor patients carefully and may restrict treatment if their BMI becomes too low or if there are signs the medication is being misused
If tirzepatide is not working after 12 to 16 weeks at adequate doses (7.5 to 10 mg or higher), discuss returning to semaglutide with your provider
They check if: Your BMI meets requirements (27+ with conditions or 30+ without) Semaglutide suits your medical history You need additional testing Sometimes providers ask for lab work to check your thyroid function, blood sugar levels, or kidney and liver health
These drugs require dose titration, particularly to reduce adverse effects like nausea and diarrhea that are common soon after starting therapy, he says
Beyond this window, progressive peptide degradation occurs, compromising research accuracy
