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Our group, working with partially deficient IGF-1 mice, has demonstrated that the liver is capable of expressing IGF-1R (which under physiological conditions it does not [99]) as a defence mechanism (peer review)

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These findings highlight the regulatory role of MAPKAPK2 in the oxidative stress response of vitiligo melanocytes and underscore its functional relevance in vitiligo pathogenesis, providing a rationale for future targeted therapies

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Small molecule inhibitors as tools to scan for active pathways do not conclusively rule out the participation of a signaling mediator if a negative result is obtained (i.e., no inhibition/augmentation of a toxic endpoint)

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Low testosterone can affect sexual function, fertility, energy

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diarrhoea)

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