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25OHD, 25-hydroxy vitamin D

This simultaneous tri-receptor engagement represents a mechanistic departure from earlier compounds in the incretin class, which targeted one or two of these receptors

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Moreover, a recent clinical study found that vitamin D at levels ~5 times greater (48 g) than that used in this report, had no effect on improving muscle strength in healthy older adults [56]

On its own its effects are modest, but combined with GLP-1 the two create a synergistic effect that amplifies both glycemic control and fat reduction beyond what either achieves alone which is why tirzepatide generally outperforms semaglutide in head-to-head comparisons

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