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For GPs who have been prescribing semaglutide off-label to treat conditions such as obesity, while the medicines regulator acknowledges that it is a serious chronic disease that is challenging to manage, at this stage it is recommending that alternatives be considered as supply is expected to remain unstable for some time

Particular focus was on IcoSema, a new drug by Novo Nordisk that combines once-weekly insulin icodec (approved in Europe and other countries, but not yet the U.S.) and semaglutide, a GLP-1 agonist

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Some patients may inadvertently change their dietary patterns whilst adjusting to the appetite effects of Ozempic