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Pregabalin, which was the first drug to gain FDA approval for diabetic neuropathy, is an anticonvulsant and analgesic that works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system
To illustrate how FcRn antagonism can be efficacious across different pathologies, we briefly describe the IgG response in some of the diseases for which FcRn antagonists have entered clinical trials and therapeutic use
The peptide pharmacokinetics paper by He et al
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Multi-mechanism research designs
