essence trial semaglutide The ACCP Endocrine and Metabolism PRN is wishing everyone a lovely holiday season 🎄✨ In your down time, here's a quick journal club review of the evaluating once-weekly 2.4 Phase 3 ESSENCE trial: Semaglutide

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Based on animal reproduction studies showing fetal harm at clinically relevant exposures, the FDA recommends that semaglutide should be discontinued at least 2 months before a planned pregnancy due to its long washout period (approximately 5 weeks after the last dose)

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So first the trial and Im just going to cut and paste from Lillys pressor on this part as to what the trial actually is: TRIUMPH-4 (NCT05869903) is a Phase 3, 68-week, randomized, double-blind, placebo-controlled study comparing the efficacy and safety of retatrutide with placebo in adults with obesity or overweight and knee osteoarthritis