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10.3389/fbioe.2025.1558757 3 AnkitB

PubChem (2026) 9

To help bypass any barriers to absorption in the GI tract, many healthcare providers recommend B12 injections for deficiency, but research shows that very high doses of oral B12 (1,000 to 2,000 mcg once a day) can normalize serum B12 levels to a similar extent with minimal side effects

For drug developers, the results illustrate how an approved kinase inhibitor's mechanism can be extended into adjacent autoimmune skin conditions, adding to a broader industry push toward oral systemic options in dermatology

Over time, this whole process helps make skin healthier, leading to a more even skin tone