Published large human clinical-trial data is not available, so a regulator-grade answer to that question does not exist
E.VickermanP.GottliebS
Recalls & Warnings November 07, 2005 FTC Stops Bogus Ads for "Bio Trim" and Other Weight-loss Products On November 7, 2005, the Federal Trade Commission (FTC) announced that under the terms of a consent agreement that it has approved, Tustin, California based Natural Products, LLC, All Natural 4 U, LLC and their owner, Ana M
4 The easing of nausea after the first weeks of treatment is consistent with, but does not prove, such adaptation
The mechanisms are well-characterized at the cellular level
Efficacy was predicted by early response to treatment [115]