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And some research suggests that metabolic benefits, including improved insulin sensitivity and cardiovascular markers, occur at doses below the standard weight loss protocol
It is administered once weekly via a subcutaneous injection
Gastrointestinal tolerability differs meaningfully between routes: oral tirzepatide may produce nausea, vomiting, or diarrhea as the medication passes through the digestive tract, while injectable tirzepatide typically generates fewer GI symptoms due to systemic delivery bypassing stomach irritation
Adapted from: AACE/ACE Obesity CPG, Endocr Pract