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In a healthy body, mast cells only degranulate (burst and release their contents) when they encounter a genuine threat, such as a parasite or a severe allergen
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For pregnant patients, semaglutide for weight management is not recommended during pregnancy, and should be discontinued if pregnancy occurs
In mice, adding it on top of genetic clearance "did not further enhance these effects." The in-vitro window between killing senescent and healthy cells is about 11-fold at best
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