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doi:10.1016/j.ejphar.2019.01.002 Dowling RJO, Goodwin PJ, Stambolic V

What is worth to summarize here is the fact that several pro-apoptotic stimuli induce an early extrusion of GSH from cells leading to a widespread mitochondrial damage and to cytochrome c release into the cytosol, the starting condition for apoptotic intrinsic pathway commitment