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If patients are not consuming enough calcium, vitamin D, and other bone-supporting nutrients, the risk of osteopenia or osteoporosis could increase over time
The first approved GLP-1 analogue for clinical use was exenatide in 2005, a peptide originally isolated from Heloderma suspectum lizard venom by John Eng in 1992 [17]
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Three distinct clinical entities have been described
However, in this case, there are numerous obstacles to cross, mainly financial and resource barriers, intellectual properties, data access barriers, biases, and liability risks (Masuda et al., 2020)
treatment with thiamine and lipoic acid
