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Tetrahydroberberrubine exhibits preventive effect on obesity by activating PGC1-mediated thermogenesis in white and brown adipose tissue

Polycystic ovary syndrome affects approximately 1 in 10 women of reproductive age, and insulin resistance underlies symptoms in up to 70% of cases

The most commonly reported adverse effects in these trials were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the broader class of GLP-1 receptor agonists

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it also has a higher risk of adverse effects and lower cost-effectiveness than semaglutides