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It is estimated that 4 million people die annually due to obesity

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Type 1 diabetes, severe recurrent hypoglycemia, or impaired awareness of low-blood-sugar symptoms typically warrant either avoidance or extremely close monitoring with mandatory insulin adjustments

Some patients may benefit from extending the time spent at lower doses before escalating

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I remember sitting in my primary care physicians office when she asked me what Id recommend for a patient wanting to lose 20 pounds in three months