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slower dose escalation Severity: Usually mild if you find your sweet spot dose Constipation More common than diarrhea Management: Increase fiber, water intake, magnesium glycinate Typically improves after 4-6 weeks Decreased Appetite (Intended) Some experience appetite too suppressed Management: Eat by the clock, not by hunger

This not only may lead to treatment interruption but also may increase the risk of malnutrition and dehydration caused by reduced intake [64]

It's about interaction, context, and timing

Am J Physiol Gastrointest Liver Physiol (2014) 307(3):G3307.10.1152/ajpgi.00329.2013 113 RonDWalterP

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Mixing them degrades potency and stability