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Moreover, these findings hold significant implications for developing novel therapeutic strategies targeting the NRF2/ARE pathway as well as other antioxidative pathways such as p53 and HIF

The loss of PCM integrity also allows deeper penetration of cytokines and enzymes, accelerating matrix breakdown (Umlauf et al., 2010)

This pattern allows some recovery while maintaining regenerative stimulus

The authors used affinity mediated DNA-encoded library selection against a privileged scaffold to identify a compound with potent inhibition against human glutathione S-transferase Mu 2