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5be), and, importantly, liver biochemistry remained stable with both short-term (23 weeks) and long-term (26 weeks) treatment (Extended Data Figs
One of the differences between both sets of experiments is between the cell conditions four days after gene transfection and the conditions used with stable cell lines due to lentiviral infection
Thereafter, a steady increase until 9 h pi and a subsequent decrease to pre-challenge counts was observed
That said, the following titration table reflects the prevailing clinical approach used by longevity-focused practitioners, calibrated against the available pharmacological data
It is important to follow recommended dosing guidelines and consult a healthcare practitioner if you are pregnant, nursing, or taking medications