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Endogenous glucagon-like Peptide-1 suppresses high-fat food intake by reducing synaptic drive onto mesolimbic dopamine neurons

We conducted RNA sequencing of three tumors each from treated and control mice and compared the differentially expressed genes with a separate in vitro experiment using cultured MDA-MB-231 cells treated with either ESA, the GPX4 inhibitor ML162, or vehicle controls

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Realistic Timelines: When Inch Loss Becomes Weight Loss The first 4-8 weeks on semaglutide typically show more dramatic inch loss relative to weight loss, driven by water loss, reduced bloating, and initial fat mobilization