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Instead of asking whether GLP-1 medications work, clinicians are beginning to ask for whom they work best and what alternative pathways should be considered when responses are incomplete. We asked our experts to explain why GLP-1s dont always work for weight loss and what alternatives are available

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23, 24 We have therefore evaluated GLP1R in human thyroid and pancreas tissues using an extensively validated GLP1R monoclonal antibody 24 that we used for immunohistochemistry and western blots and that we compared with results of GLP1R autoradiography in the same tissues