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By applying NAPstars in combination with selective impairment of the glutathione and thioredoxin antioxidative pathways under acute oxidative challenge, we find an unexpected and conserved role for the glutathione system as the primary mediator of antioxidative electron flux

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Multifunctional synergistic nanoscale systems Nanoparticles can improve RIRI through multifunctional synergistic effects, with mechanisms encompassing targeted delivery, antioxidant properties, anti-inflammatory effects, and inhibition of cell death

ACMSD: a novel target for modulating NAD(+) homeostasis

Among them, neutrophils are the most abundant and are essential for detecting pathogens and initiating immune cascades through processes such as swarming, cytokine production, degranulation, phagocytosis, and the formation of neutrophil extracellular traps (NET) ( Figure 3 )