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Orlistat (Xenical, Alli) reduces fat absorption in the gut and is the only effective over-the-counter weight loss pill available, says Johnson-Rabbett, though it can have significant gastrointestinal side effects

This surface adsorption effect is more pronounced with lower peptide concentrations

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For others, especially those who had adjusted their eating habits to align with the medications effects on appetite and fullness, the transition can feel disorienting in a different way

Primarily triggered by food consumption, GLP-1 release occurs 10 15 minutes after eating