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Overall, the metabolic impact of resmetirom can be likened to pharmacological simulation of mild hyperthyroidism localized to hepatocytes, thus avoiding any systemic complications from excess thyroid hormone [16]
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K.h, Tarnovskaya, S
NCT02305381
This 1993 model has been validated and expanded over the past three decades, with additional mechanisms extensively reviewed [61]
Given that sensory or gastrointestinal adverse effects, such as dysgeusia and persistent nausea, can impair nutritional intake and lead to early treatment discontinuation (particularly in vulnerable populations) future research must incorporate rigorous sensory testing, larger and more diverse cohorts, and adherence-related outcomes to clarify how incretin therapies influence taste perception and long-term eating behavior (153, 157, 161)
