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For comparison, tirzepatide (Mounjaro, Zepbound) has a slightly lower constipation rate at 14-17% across doses, possibly because the GIP receptor component partially counteracts GLP-1's motility effects in some patients

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This is the side effect people are talking about, even though its not front-and-center in the clinical literature

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Compound Tirzepatide has shown significant promise in medical studies for addressing a variety of metabolic concerns

Originally developed to treat diabetes, GLP-1 receptor agonists mimic the action of glucagon-like peptide 1, which stimulates insulin production and lowers blood sugar levels