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Reward circuitry One of the less expected findings concerns reward

Wait until the tablet has fully dissolved, then continue holding for an additional 1-2 minutes before swishing and swallowing

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Our data suggest exendin-P5 may induce a looser coupling between the ligand TMD and G s binding sites, potentially linked to the more short-lived interactions with TMD residues, resulting in higher efficacy due to faster G s conformational transitions associated with nucleotide exchange and faster G s dissociation

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