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In particular, GSH can effectively scavenge ROS and maintain intracellular reductive homeostasis, further promoting the occurrence and development of tumor (Yang et al., 2020

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188 LCN2 inhibits ferroptosis by enhancing GPX4 and SLC7A11 expression and reducing intracellular iron levels, and LCN2 overexpression in colon cancer cells leads to resistance to 5-fluorouracil (5-FU) by inhibiting ferroptosis