Spectra scans were acquired in Q-Exactive mass spectrometry instrument (Thermo Scientific, USA), coupled to a nano UHPLC system via a nanoelectrospray ion source
23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids
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Kloppenburg M, Berenbaum F
Christopher M Stevens for lab assistance
Beyond their insulinotropic effects, GLP-1R and GIPR signaling also influences lipid metabolism by modulating hepatic lipid handling and adipose tissue function