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The tissue-specific distribution of beta-3 receptors (concentrated in fat tissue) further enhances selectivity

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FIGURE 7 Discussion In animal experiments, we verified the therapeutic effect of berberine on T2DM and the function improvement of islet cell

Tatarkiewicz K, Smith PA, Sablan EJ, Polizzi CJ, Aumann DE, Villescaz C, Hargrove DM, Gedulin BR, Lu MG, Adams L, Whisenant T, Roy D, and Parkes DG