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The following is a review of the preclinical and clinical studies examining the role of GLP-1R agonists on the vascular endothelium and HFpEF: Data from preclinical studies In a study on non-diabetic mice models with arterial hypertension (simulating preconditions for HFpEF), Liraglutide treatment improved blood pressure and cardiac hypertrophy in angiotensin II-induced arterial hypertension independent of glucose/insulin modulation leading to the reversal of cardiac hypertrophy
CJC-1295/Ipamorelin is not FDA approved as a combination product, and neither individual peptide has FDA approval for human therapeutic use
Ethics declarations Competing interests J.R., G.D., J.F., D.C.H
Dalton, TP
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Lancet 2 , 2324 (1968)
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