These cases underscore the need for more predictive preclinical models, improved safety evaluation, and strategies to overcome tumor heterogeneity
Do not attempt to microdose or alter your prescribed medication regimen without seeking medical advice.
Patients should not attempt to "wait out" severe abdominal pain or assume it represents a normal medication side effect
If gastrointestinal symptoms become severe or persistent, dose reduction or temporary treatment interruption may be necessary, and patients should consult their healthcare provider
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Pressley JC, Louis ED, Tang MX, Cote L, Cohen PD, Glied S, et al