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Gene set enrichment analysis was performed using fgsea v1.30.0 using mouse-ortholog Hallmark genesets from MsigDB loaded with msigdbr v7.5.1 58,59

The primary mechanism involves copper delivery to dermal tissues where this essential cofactor supports numerous enzymatic processes including collagen synthesis, elastin production, glycosaminoglycan formation, and antioxidant enzyme activation

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Regulatory agencies may need to implement stricter guidelines to prevent inappropriate prescribing and ensure that these drugs are used in medically justified scenarios