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Loading For deficiency without neurological features, the standard loading regimen is hydroxocobalamin 1mg intramuscularly three times a week for two weeks, six injections in total

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STAT3-targeting siRNA (siSTAT3, batch number 1348C5) was purchased from GeneChem

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In vivo experiments showed early activation of complement genes such as C4 and C4A , with significant upregulation of classical pathway components ( C1q , C3 ) by day 7