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Figure 2 4.1 Oxidative stress and ROS accumulation Varicocele induces hemodynamic disturbances that lead to increased testicular temperature, hypoxia, and metabolic stress, thereby triggering a cascade of biochemical and structural injuries, among which oxidative stress represents the most central and decisive pathological mechanism (56)

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Increased oxidant-induced apoptosis in cultured nondividing human retinal pigment epithelial cells

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NRF2 addiction in cancer cells In many human cancers, the transient and inducible nature of the KEAP1-NRF2 system is lost