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For chronic constipation, NICE CKS recommends macrogol as the first-line treatment for most adults, with bulk-forming agents as an alternative when appropriate

However, this has not always been the case and it has taken 2 changes in legislation to enable water to be distributed to drug users

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat

The current evidence primarily comes from retrospective studies and case reports

Always consult with your physician before using this or any other dietary supplement product

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