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High Mutational Concordance Between Next Generation Sequencing Profiles of Colorectal Cancer and Pulmonary Metastases

Farago M, Dominguez I, Landesman-Bollag E, Xu X, Rosner A, Cardiff RD, Seldin DC

Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH

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This helps reduce discomfort during injection

Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood