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J Pediatr 121:641646 Walker JL, Crock PA, Behncken SN, Rowlinson SW, Nicholson LM, Boulton TJC, Waters MJ (1998) A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-1 and luteinizing hormone-releasing hormone analogue

These are most pronounced during dose escalation and tend to diminish over time