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Key Findings: Participants: 338 obese adults Duration: 48 weeks Average weight loss: 17.5% to 24.2% depending on dose Metabolic improvements: Better insulin sensitivity, reduced inflammation markers These results put Retatrutide ahead of many current obesity drugs, making it one of the most promising new weight loss peptides of 2025

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Figure 1 Collectively, these data show that acute liraglutide treatment significantly improves glucose tolerance, insulin sensitivity and impaired hepatic gluconeogenesis in SKO mice, with the greatest effects being observed in female SKO mice