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doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao

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Safety Profile and Toxicological Considerations Preclinical Safety Studies Comprehensive preclinical safety evaluations of BPC-157 demonstrate a remarkably favorable toxicological profile

The original studies focused on protecting the gastrointestinal tract (stomach, duodenum), and subsequent ones expanded the scope to tendons, ligaments, muscles and even the nervous system