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The presence of the second active-site cysteinyl residue in PfGrx improves the reactivity of the ternary complex but does not form an intramolecular disulfide bond in contrast to a dithiol mechanism

This article covers the pharmacology of both compounds, what glutathione actually does in the body versus what it's marketed to do, and the specific scenarios where combining them might make clinical sense

2013 May

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If a cycle isn't doing what you expected, we revisit it rather than waiting out the calendar