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These figures are consistent with the reported half-life and standard "first-order" drug elimination used in clinical pharmacology

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At a willingness-to-pay threshold of GBP 20,000 per QALY gained, the probabilities of oral semaglutide 14 mg being cost-effective versus empagliflozin 25 mg, sitagliptin 100 mg and liraglutide 1.8 mg were 59.9, 77.6 and 79.5%, respectively, while at a willingness-to-pay threshold of GBP 30,000 per QALY gained, these probabilities were estimated to be 64.3, 80.2 and 74.7%, respectively (Fig