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McDonald suspects that GLP-1 medicines, as they regulate hunger and digestion hormones, also trigger other metabolic pathways

Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes Vlado Perkovic, Katherine R Tuttle, Peter Rossing, Kenneth W Mahaffey, Johannes F E Mann, George Bakris, Florian M M Baeres, Thomas Idorn, Heidrun Bosch-Traberg, Nanna Leonora Lausvig, Richard Pratley

It mimics the action of the natural hormone but has improved stability and a longer half-life, allowing for less frequent dosing (12)

Scholars have corroborated this concern, with one 2024 systematic review noting that up to 40% of the weight loss on semaglutide can come from lean mass like muscle

M.MoralesA.BlascoC.ColellA.MariM.Garcia-RuizC.et al (2005)

[1] [2] Unlike many conventional tablets, Rybelsus requires specific packaging to maintain its stability and efficacy