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If medicines that normally require food are consumed during a fast, their effects can become exaggerated or dangerously unpredictable.In cases like Shefalis, where injections and pills were taken during a fast, even a routine dosage could have contributed to the body going into shock or developing cardiac symptoms

Exendin-4 improves cardiovascular function and survival in flow-induced pulmonary hypertension

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Chronotropic refers specifically to rate, meaning these drugs tend to speed up how fast the heart beats

and traumatic brain injury (Ismail et al., 2020)